Diseases causing inherited retinal degeneration in humans, such as retinitis pigmentosa and macular dystrophy, are genetically heterogeneous and clinically diverse. More than 40 genes causing retinal degeneration have been mapped to specific chromosomal sites; of these, at least 10 have been cloned and characterized. Mutations in two proteins, rhodopsin and peripherin/RDS, account for approximately 35% of all cases of autosomal dominant retinitis pigmentosa and a lesser fraction of other retinal conditions. This target article reviews the genes and mutations causing retinal (...) degeneration and proposes mechanisms whereby specific mutations lead to particular clinical consequences, that is, the relationship between genotype and phenotype. Retinitis pigmentosa and macular dystrophy are genetically heterogeneous diseases that cause retinal degeneration in humans and often result in severe visual impairment or blindness. Although many of the genes causing these diseases have not been identified, three photoreceptor-specific proteins have been implicated: rhodopsin, peripherin/RDS, and the P-subunit of rod phosphodiesterase. Mutations in the genes for these three proteins can cause either dominant retinitis pigmentosa, recessive retinitis pigmentosa, dominant congenital stationary night blindness, or dominant macular degeneration. Why this multiplicity of clinical phenotypes? Our target article summarizes the genetic and biochemical background to this question and proposes a number of possible explanations. Discussion focuses mainly on 73 distinct disease-causing mutations of rhodopsin. We feel that rhodopsin and other photoreceptor proteins can serve as model systems for unraveling the connection between genotype and phenotype, not only for inherited retinal diseases but for other degenerative disorders as well. (shrink)

Recent findings emphasize the complexity, both genetic and functional, of the manifold genes and mutations causing inherited retinal degeneration in humans. Knowledge of the genetic bases of these diseases can contribute to design of rational therapy, as well as elucidating the function of each gene product in normal visual processes.

Is helping those whose subsistence needs are not meet a matter of charity or an obligation? What role should ordinary citizens of developed nations play? In a globalized world, the causes, connections, and responsibilities become complicated. Agriculture subsidies that keep food prices low for many in relatively rich countries may, for example, negatively impact poor farmers in developing countries. Students in Ethics/Philosophy 352 report on their project examining whether, and to what extent, a true obligation to aid exists.

El uso de aulas inteligentes mejora la competencia lingüística del alumnado universitario. Los objetivos de esta investigación son esclarecer cómo están constituidos estos espacios y mostrar la efectividad de los avances metodológicos para promover un aprendizaje colaborativo. Los resultados se obtienen de una encuesta dirigida a diferentes universidades. Se aboga por la elaboración de un e-portafolio como evidencia del proceso de enseñanza-aprendizaje. La propuesta sebasa en la teoría socioconstructivista y en la resolución de problemas relacionadoscon la ortografía. En suma, se (...) deben crear aulas inteligentes en las universidades ymejorar la integración de las TIC en la docencia. (shrink)

Informed consent is a perennial topic in bioethics. It has given the field a place in clinical practice and the law and is often the starting point for introductory instruction in medical ethics. One would think that nearly everything has been said and done on this well-worn topic.

Neuropsychiatric disorders introduce distinct challenges to clinical decision-making. Affected patients often experience impairments or absences in rationality, lucidity and cogni-emotional capacities, rendering it difficult for them to engage in the decision-making process. In turn, dynamics of the patient-physician relationship become strained, including when physicians employ bioethical principlism or moral case deliberation to arrive at ethically justified courses of action–both of which require sufficient communication and rationality that may be impaired or altogether absent in the presence of psychopathology. The complexity of (...) neuropsychiatric conditions therefore compels interrogation towards how ethics consultations are currently constructed and conducted when full communication or rational decision-making cannot be assumed. Delany et al, for example, present a robust, methodical framework for ethical deliberation.1 Such methodologies for facilitating ethical decision-making, although valuable in predominant contexts, assume full participant engagement and decision-making capacities (eg, independent moral agency). Neuropsychiatric disorders complicate this assumption, making it difficult for patients with limited decision-making capacity to engage meaningfully in proposed ethics consultations.2 This paper will explore how neuropsychiatric disorders complicate the assumptions of full participant engagement underlying ethical frameworks. It will argue that, by adapting ethics consultations to function as a ‘mental prosthesis’, clinicians can better navigate the ethical challenges posed by neuropsychiatric disorders, helping to ensure that patient autonomy is upheld even in cases of impaired cognitive …. (shrink)

Background The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To test MedLine's representation of this field, we chose the topic of death and dying in the three major monotheistic religions. Methods (...) We searched MedLine using PubMed in order to retrieve and thematically analyze full-length scholarly journal papers or case reports dealing with religious traditions and end-of-life care. Our search consisted of a string of words that included the most common denominations of the three religions, the standard heading terms used by the National Reference Center for Bioethics Literature (NRCBL), and the Medical Subject Headings (MeSH) used by the National Library of Medicine. Eligible articles were limited to English-language papers with an abstract. Results We found that while a bibliographic search in MedLine on this topic produced instant results and some valuable literature, the aggregate reflected a selection bias. American writers were over-represented given the global prevalence of these religious traditions. Denominationally affiliated authors predominated in representing the Christian traditions. The Islamic tradition was under-represented. Conclusion MedLine's capability to identify the most current, reliable and accurate information about purely scientific topics should not be assumed to be the same case when considering the interface of religion, culture and end-of-life care. (shrink)

La teología del sacerdocio de Joseph Ratzinger se condensa en un concepto: “misión”. Los clásicos principios de origen, institución, contenido de la misión o sucesión apostólica quedan articulados desde la “misión”. El presente artículo es una aproximación a esta categoría en la teología del teólogo alemán. El presupuesto es la comprensión del sacerdocio que Ratzinger tiene. Tras el mismo, sigue un estudio más específico sobre la comprensión del término “misión”. Este se descubre como un eje que articula dos puntos: (...) origen del ministerio y destinatarios del mismo. El estudio concluye con algunas implicaciones sobre la teología del sacerdocio y sobre su configuración concreta en el momento presente. (shrink)

This paper analyses and criticizes Joseph Raz's attacks on coherentist theories. It is argued that Raz's characterisation of epistemic coherence theories is too narrow and that his criticism of constitutive coherence theories is based on a conceptual mistake in his own description. The study is an indirect argument to rethink coherence theories of law and adjudication within a more powerful framework than that propounded by Raz.

La Revolución Francesa alteró profunda mente la vida europea y su influencia no tardó en llegar a América. Muy pronto surgieron frente a ella posturas que se oponían a sus postulados ideológicos y políticos. Dos de estas posturas llaman la atención: la de Edmund Burke y la de Joseph de Maistre. Ambas reacciones cuestionan la Revolución desde una perspectiva conservadora, pero toman caminos diferentes. La de Burke dará origen a un conservadurismo posibilista y procedimental, compatible con el liberalismo, mientras (...) que la de De Maistre inicia una tradición conservadora contrarrevolucionaria y maximalista que derivará en el integrismo. (shrink)

This article contends that Dworkin's notion of ‘genuine’ theoretical disagreements, which is a fundamental pillar in his criticism of legal positivism and semantic disagreements, requires a realist reinterpretation. This view is defended according to two core arguments. First, a realist reinterpretation of ‘genuine’ theoretical disagreements enables Dworkin to avoid semantic criticisms such as the one advanced by Joseph Raz, who propounds a sophisticated model of criterial semantics to explain theoretical disagreements. Second, to make intelligible the distinction between theoretical and (...) semantic disagreements in law, we need to resort to realist elements. The conclusion is striking and in clear contradiction with Dworkin's ametaphysical and epistemic abstinence. The article shows that there is a problematic tension within Dworkin's constructivist project and that he should revise either its ametaphysical view and epistemic abstinence, or notions such as ‘genuine’ theoretical disagreements. (shrink)

The essays in this book deal with philosophical issues in the thought of Maimonides. Included are: The Literary Character of the Guide for the Perplexed by Leo Staus, The Purpose of the Law According to Maimonides by Miriam Galston, and Essence and Existence in Maimonides by Alexander Altmann.

The author argues that, while logical rigor requires Whiteheadians to emphasize the ontological priority of the notion of actual entity as a self-constituting subject of experience for the proper understanding of physical reality. Whitehead's understanding of the key category of society in his metaphysics, especially the way that societies and their constituent actual entities reciprocally "constrain " one another's existence and activity and the way that societies are hierarchically ordered to one another within the evolutionary process will presumably have more (...) empirical resonance with natural scientists in their own efforts to understand the emergence of life from non-life, the progressive growth of self-awareness among higher-order animal species, etc. So, in dialogue with natural scientists, why not start with what is psychologically more interesting to the listener? (shrink)

A bilingual translation of Zhu Xi's 朱熹 Yixue qimeng 易學啟蒙 (1186).

Beyond Decolonial African Philosophy dives into decoloniality discourse, challenging some of its shortcomings and offering alternative perspectives on the nature of Africanity and Afrotopia (Africa's better future) from leading African philosophers. Beginning with an overview of philosophy in contemporary Africa, the first half of the book goes on to critically interrogate and rethink decoloniality's deconstructivist approach. The second half of the book considers a range of alternative new conceptualizations of Afrotopia and Africanity that transcend decolonial theory, drawing on constructivist and (...) creative approaches. The book considers key questions such as: Is Africanity immutable (essentialism), or mutable (nominalism)? Should we emphasise idealist, identitarian concerns, or pragmatic, developmentarian concerns? Should we prioritise African agency, or structures and circumstances? Should Africa embrace hybrid interculturality and creative self-manifestive identity or essentialist purity? Drawing on rich insights from African philosophers across the continent, this book challenges students and researchers to think beyond the concept of decolonization to alternative forms of African identities and African futures. (shrink)

Long a source for quotations, fragments, and factoids, the Noctes Atticae of Aulus Gellius offers hundreds of brief but vivid glimpses of Roman intellectual life. In this book Joseph Howley demonstrates how the work may be read as a literary text in its own right, and discusses the rich evidence it provides for the ancient history of reading, thought, and intellectual culture. He argues that Gellius is in close conversation with predecessors both Greek and Latin, such as Plutarch and (...) Pliny the Elder, and also offers new ways of making sense of the text's 'miscellaneous' qualities, like its disorder and its table of contents. Dealing with topics ranging from the framing of literary quotations to the treatment of contemporary celebrities who appear in its pages, this book offers a new way to learn from the Noctes about the world of Roman reading and thought. (shrink)

Forthcoming in Jennifer Oldstone-Moore, ed., The Oxford Handbook of Confucianism (New York: Oxford University Press).

A translation of Zhu Xi's 朱熹 Zhouyi benyi 周易本義 (1188).

This critical review of Responses to the Enlightenment focuses on the relationship between faith and reason as advanced by Hendrick Hart and William Sweet, respectively. It does so in the context of Enlightenment critique of faith, from which both Hart and Sweet seek to salvage religious faith. While faith as trust is admitted to be performative (Hart), faith is also belief with cognitive content (Sweet). However, faith and reason, as I contend, stand in a dialectical relationship between the need for (...) commitment and understanding at the root of religious as well as secular traditions or worldviews. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dependent Co-Origination and Universal IntersubjectivityJoseph A. Bracken, SJTwo essays in a recent issue of Buddhist-Christian Studies dealt with the topic "Buddhist and Christian Views of Community." The first essay, by Rita Gross, was a careful analysis of the way in which the separation of home and workplace in contemporary Western society has tended to reduce effective community life to the nuclear family and thus pose significant disadvantages to everyone (...) involved (not only mothers, fathers, and their children but also non–family members, friends, and neighbors) within the broader civic community.1 A consumer-oriented culture catering to individual needs and desires has arisen to compensate for the pervasive feeling of loneliness and emptiness created by the relative lack of significant interpersonal relationships. In the second essay Donald Mitchell recounted the origin and unexpected growth of the International Focolare movment of which he is a longtime member.2 He noted how the founder of the movement, Chiara Lubich, and her women friends found inspiration for living together and working for the poor and the homeless around them in what they saw as the self-giving love of the three divine persons of the Christian doctrine of the Trinity both for one another and for all their creatures. This movement over time broadened to include first Protestant members, then Jews, Muslims, Buddhists, and Hindus, all drawn by the goal of richer life in community along with group efforts to assist the underprivileged of this world.My own contribution to the topic of Buddhist and Christian views of community will focus on the same communitarian model of the doctrine of the Trinity that originally inspired Lubich and her followers in the years during and after World War II, but my remarks will be more philosophically oriented. Following the lead of the late Colin Gunton in his book The One, the Three and the Many,3 I will analyze the communitarian model of the Trinity for its value in setting forth a new paradigm for the relationship of the One and the Many. As Gunton perceptively notes in the early chapters of his book, Western civilization seems to be still preoccupied with a basically Platonic understanding of the One and the Many in which the One enjoys primacy over the Many as their transcendent principle of order and intelligibility.4 As a result, even though freedom and individual self-expression are theoretically prized in Western societies, in point of [End Page 3] fact there is a great deal of uniformity and even repression of individual differences so as to conform to the cultural standards imposed by some dominant individual or minority group within each society. In the end people seem to fear the threat to personal security represented by wide diversity and plurality more than they value their individual liberty.Looking to the doctrine of the Trinity set forth by the Greek-speaking fathers of the Church, however, Gunton finds a new paradigm for the One and the Many whereby the One is emergent out of the interplay of the Many with one another rather than transcendent over the Many as their necessary principle of order and intelligibility.5 The Many are defined by their internal relations to one another rather than by their common relation to an external One. The community thus achieved is a differentiated unity, not only tolerating differences of the Many among themselves, but even fostering those differences so as to produce in the end a more complex form of community. The application to the Christian doctrine of the Trinity is obvious. The three divine persons are strictly defined with respect to one another; each of them has no self-identity apart from relation to the other two persons. Yet together they co-constitute the reality of the one God, a richly differentiated rather than blandly homogeneous unity.6The application to human beings and their membership in various communities, of course, is not so obvious. But Gunton believes that three principles or "transcendentals" for the understanding of the relation of human beings with one another and with God are at hand, given careful study of this communitarian model of the Trinity: namely, perichoresis, substantiality or... (shrink)

The authors delineate the nature and neglect of integrity capacity and global business citizenship by world business leaders. They discuss how the philosophical analysis of moral and economic complexity enhances judgment integrity capacity and global business citizenship. Finally, the authors recommend positive action steps to improve global business citizenship and leadership integrity capacity through a balanced and inclusive pluralistic economic philosophy.

This unique edited collection illuminates Paul Ricoeur's engagement with Scripture. The contributors include one of the primary translators, several who studied at the University of Chicago, and some of this generation's noted Ricoeur scholars. The essays discuss Hebrew and Christian Scripture, hermeneutics, and biblical scholarship.

String theory is often depicted as the best chance for natural science to find a Theory of Everything. Whiteheadians may object that only a philosophical cosmology such as Whitehead presents in PR can “frame a coherent, logical, necessary system of general ideas in terms of which every element of our experience can be interpreted” (PR 3). But then they have to show that Whitehead’s scheme and string theory fit together nicely, with each helping to resolve residual problem areas in the (...) other. The present article conjectures that the tiny vibrating strings postulated by string theory and the superjects of individual actual entities might correspond to the “final, real things of which the world is made up” (PR 18). Likewise, the extra spatial dimensions required by the mathematics of string theory might be more intelligible in terms of the interaction of different levels of subsocieties within a Whiteheadian structured society. (shrink)

This article draws on key models of monitoring and blockholding articulated in the incomplete contracts theory of the firm. Under incomplete contracts theory, different governance systems have incentive structures that entail different tradeoffs—tradeoffs between ownership concentration and liquidity, between monitoring and management initiative, and between private rent-seeking and activity benefiting shareholders as a group. The tradeoffs delimit opportunities for productive cross-reference. More specifically, blockholder systems, such as those in Europe, subsidize monitoring by permitting blockholders to reap private benefits of control (...) through self-dealing and insider trading. Market systems, such as those in the United States and Britain, regulate such private rent-seeking toward the end of maintaining an institutional framework that supports diffuse share ownership and liquid trading markets. It follows that a legal framework conducive to blockholding may be ill-equipped to foster dispersed equity ownership and thick trading markets and that a legal framework conducive to liquid trading markets may have properties that discourage blockholding. This gives rise to questions for law reform agendas on both sides of the Atlantic. In the United States, proponents ask for deregulation of controls on institutional investors, looking to encourage blockholding and more effective monitoring. In Europe, proponents ask for stronger securities regulation, looking to encourage deeper trading markets. This article suggests that each reform program may lead to disappointing results because neither assures conforming adjustments to the pertinent actors’ incentives. Alternatively, strict reforms that materially change prevailing incentive patterns could perversely destabilize workable arrangements without assuring the appearance of more effective alternatives. (shrink)